Akciğer kanserli hastaların plazmalarında poliamin yolağına ait enzim düzeyleri ve oksidatif stres indeksi tayini


Thesis Type: Postgraduate

Institution Of The Thesis: Sivas Cumhuriyet University, Tıp Eğitimi, Temel Tıp Bilimleri Bölümü, Turkey

Approval Date: 2014

Thesis Language: Turkish

Student: SERKAN KAPANCIK

Consultant: Veysel Kenan Çelik

Abstract:

In this study, enzyme levels of polyamine pathway and oxidative stress index were observed among 36 lung cancer patients and 36 healthy people who are involved to control group. Objective of this study is to determine these parameter levels on lung cancer and then compare differences to control group. Ornithine Decarboxylase(ODC) level (P=0,001, P<0,05), Agmatinase level (P=0,001, P<0,05), Arginase enzyme activity (P=0,001, P<0,05), Total Antioxidant Capacity(TAK) (t=3,14, P<0,05), Total Oxidant Capacity(TOK) (P=0,001, P<0,05), Oxidative Stress index(OSİ) (P=0,001, P<0,05) differences have been found statistically significant between control group and patients group. On the other hand, Arginine Decarboxylase(ADC) level (P=0,424, P>0,05) and Ornithine level (t=0,17, P>0,05) differences have been found statistically pointless between the patients and control group, In this study, it was observed that ornithine decarboxylase, agmatinase levels, arginase enzyme activity, total oxidant capacity and oxidative stress index among lung cancer patients were decreasing. It was also found that total oxidative capacity was increasing while total antioxidant capacity was decreasing. And this situation naturally led oxidative stress index to increase. According to our study's results, probable increment on polyamine level may aggravate polyamine relation cancer's process. Furthermore, it isn't known wheather increment of oxidative stress can effect occuring lung cancer or not still if this increment happens during the progress of disease this could effect cancer's prognosis in a bad way.