Oral lökoplaki ve oral skuamöz hücreli karsinomda ghrelin düzeylerinin immünohistokimyasal olarak değerlendirilmesi

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Thesis Type: Dental Specialty

Institution Of The Thesis: Sivas Cumhuriyet University, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Turkey

Approval Date: 2016

Thesis Language: Turkish

Student: GÜL KAÇMAZ

Supervisor: ABDULLAH İLKER ÖZEÇ

Open Archive Collection: AVESIS Open Access Collection

Abstract:

Biomarkers are proteins or genes that can be differentially expressed in cancer, pre-malign and normal tissue and the use of biomarkers may help to improve prediction of cancer transformation. The aim of this study was to investigate whether ghrelin is differently expressed in normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma (OSCC). Preparations of deparaffinized blocks obtained from the pathology archives of 55 previously diagnosed cases of normal oral mucosa (n=15), oral leukoplakia with hyperkeratosis without dysplasia (n=18) and OSCC (n=22) were stained immunohistochemically with specific antibodies to evaluate ghrelin expression. Ghrelin was expressed in 64% of normal oral mucosa, 66% of oral leukoplakia, but in only 8% of OSCC. Compared with the other two groups, the mean ghrelin expression decreased significantly (p<0,05) in the OSCC group. Ghrelin expression is decreased in OSCC compared with normal oral mucosa and oral leukoplakia. The ghrelin levels were similar in oral leukoplakia and normal oral mucosa. Ghrelin expression changes with oral carcinogenesis may be a biomarker for determining increased malignant potential.