Akademik Veri Yönetim Sistemi
Türk S. (Yürütücü), Kıvrak M. B., Takcı A., Bölükbaş B., Coşkun A.
Diğer Uluslararası Fon Programları, 2023 - 2024
Metabolomics is a branch of "omics" research primarily concerned with the high-throughput identification and quantification of small molecule (<1500 Da) metabolites in the metabolome. Metabolomics is increasingly applied to the identification of biomarkers for disease diagnosis, prognosis and risk prediction. Nuclear magnetic resonance (NMR) spectroscopy is a unique technique that can be applied with high resolution as the first ex vivo metabolic screening tool (NMR metabolomics) and subsequently translated into in vivo NMR spectroscopy protocols.
Small ruminants, particularly native breed kinds, play a significant role to the livelihoods of a considerable part of the human population in the tropics from socio-economic aspects. Thus, combined trials with emphasis on administration, nutrition and genetic progress to improve animal outputs are of decisive significance. Economical and biological efficiency of sheep production enterprises generally improves by increasing productivity and reproductive performance of ewes.
Pregnancy toxemia (PT) is a metabolic disorder that occurs during the final stage of gestation when energy requirements increase by 70 %–80 %. The disease commonly affects small ruminants, and the incidence can be as high as 20 % in herds. Diagnosis is usually based on clinical signs and biochemical parameters. Although PT is a common disease, there is still no effective and definitive treatment. Therefore, disease mortality may be up to 80 %. Pregnant ewes may die even during treatment, and even if they recover, premature births, abortions, and stillbirths may occur. If the ewe does not respond to treatment, delivery can be stimulated, or an emergency cesarean section can be performed to save the offspring.
PT is a metabolic disease and the dynamics of this disorder are still unclear. Metabolomics-based technologies are starting to be used for biomarker identification, disease diagnosis, and mechanism research in ruminants. Given this situation, we aim to find and integrate NMR spectroscopy-based metabolomics into the field to assess the metabolic status of sheep, early detection of PT in the herd, disease staging and prognosis. In addition, in the project, we aim to contribute to increasing productivity in animal husbandry by reducing losses in ovine breeding and to work on sustainability dynamics aiming to develop new approaches in order to realize the potential in the herds to the maximum.