Matrıx Metalloproteınase-9 Expressıon In Natural Infected Dogs Wıth Parvovırus

Karayiğit M. Ö. (Executive), Karataş Ö.

Project Supported by Higher Education Institutions, 2019 - 2020

  • Project Type: Project Supported by Higher Education Institutions
  • Begin Date: January 2019
  • End Date: February 2020

Project Abstract

Canine parvoviral enteritis has, since its emergence in 1978, been common in young dogs. After ingestion, the virus attacks rapidly dividing cells in the intestinal tract and bone marrow, causing severe vomiting, diarrhoea, fever, rapid dehydration, lethargy and decreased activity. MMPs are crucial for embryonic development, differentiation, proliferation, and regeneration of tissues. An imbalance between MMPs activating and inhibiting factors, however, results in a plethora of diseases including intestinal inflammation, arthritis, atherosclerosis or cancer. Importantly, expression levels of MMP-9 is upregulated in intestinal inflammation models and in patients suffering from human inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis. The aim of this study is to investigate the role of MMP-9 in the intestinal infection of dogs with parvovirus. In this study, intestinal tissues of 21 dog naturally infected with parvovirus were stained with MMP-9 antibody and five normal healty dog tissues were used as control. As a result, MMP-9 expression from intestinal tissues of dogs with parvovirus-infected occurred while control tissues did not expression. These results indicate that MMP-9 expression might have an impact on the pathogenesis of parvovirus-induced enteritis in dogs.