Regulatory peptide Nesfatin-1 and its relationship with metabolic syndrome


TEKİN T., ÇİÇEK B., Konyaligil N.

Eurasian Journal of Medicine, cilt.51, sa.3, ss.280-284, 2019 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/eurasianjmed.2019.18420
  • Dergi Adı: Eurasian Journal of Medicine
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.280-284
  • Anahtar Kelimeler: Metabolic syndrome, Nesfatin-1, Obesity, Peptide
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Metabolic syndrome is associated with a group of conditions abdominal obesity, high triglyceride levels, reduction in low-density lipoprotein, increased blood pressure, and increased fasting blood glucose. Hence, it poses a risk for type 2 diabetes and cardiovascular diseases. The prevalence of metabolic syndrome increases with age. Nesfatin-1, which affects different systems, has recently been discovered as a regulatory peptide molecule. With the discovery of nesfatin-1, it has been reported to inhibit the intake of nutrients and have significant regulatory effects on energy metabolism. As nesfatin-1 is present in both central and peripheral tissues, it is thought to have many functions. In addition to its suppressive effect on food intake, nesfatin-1 has also been reported to have an effect on the blood glucose level for regulating cardiac functions and affecting obesity by providing weight loss. Considering the effects of nesfatin-1, it may be associated with metabolic syndrome.