ANALYSIS OF IL-6, IL-10 AND NF-kappa B GENE POLYMORPHISMS IN AGGRESSIVE AND CHRONIC PERIODONTITIS

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TOKER H., Gorgun E., KORKMAZ E. M.

CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH, cilt.25, sa.2, ss.157-162, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.21101/cejph.a4656
  • Dergi Adı: CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.157-162
  • Anahtar Kelimeler: periodontitis, polymorphism, NF-kappa B, IL-6, IL-10, INTERLEUKIN-10 GENE, PROMOTER POLYMORPHISMS, INFLAMMATORY DISEASES, NFKB1 PROMOTER, ASSOCIATION, SUSCEPTIBILITY, METAANALYSIS, POPULATION, EXPRESSION, HAPLOTYPE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-kappa B(NF-kappa B). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-kappa B1-94ins/del)) and chronic/aggressive periodontitis.