Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats

Avci O., TaŞkiran A. Ş.

Turkish journal of medical sciences, vol.50, pp.2048-2058, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2005-256
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2048-2058
  • Keywords: Anakinra, morphine analgesia, morphine tolerance, oxidative stress, endoplasmic reticulum stress, PROINFLAMMATORY CYTOKINES, NEUROPATHIC PAIN, CONTRIBUTES, HYPERALGESIA, IMPAIRMENT, EXPRESSION, APOPTOSIS
  • Sivas Cumhuriyet University Affiliated: Yes


Background/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1 beta's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance.