Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats
Turkish journal of medical sciences, vol.50, pp.2048-2058, 2020 (SCI-Expanded)
Article / Article
Turkish journal of medical sciences
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
Anakinra, morphine analgesia, morphine tolerance, oxidative stress, endoplasmic reticulum stress, PROINFLAMMATORY CYTOKINES, NEUROPATHIC PAIN, CONTRIBUTES, HYPERALGESIA, IMPAIRMENT, EXPRESSION, APOPTOSIS
Sivas Cumhuriyet University Affiliated:
Background/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1 beta's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance.