HIGH MOBILITY GROUP BOX-1 LEVELS IN SCHIZOPHRENIA: POTENTIAL BIOMARKER OF REMISSION PHASE

YILMAZ N., YELBOĞA Z., YILMAZ Y., DEMİRPENÇE Ö.

JOURNAL OF MEDICAL BIOCHEMISTRY, vol.40, no.3, pp.295-301, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5937/jomb0-28108
  • Journal Name: JOURNAL OF MEDICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.295-301
  • Keywords: schizophrenia, HMGB-1, remission and acute exacerbation phase, HYPOTHESIS, PSYCHOSIS, HMGB1
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

Background: Schizophrenia is a chronic mental disorder, characterized byacute exacerbation and remission phases.Immune system has a role in the pathophysiology of schizophrenia. High mobility group box-1 (HMGB-1) is a macrophage secreted protein activating immune cells to produce cytokines. The aim of this study was to evaluate HMGB-1 levels among patients with schizophrenia both in acute exacerbation and remission phases.