Detection of Anaplasma capra in Patients with Suspected Crimean-Congo Hemorrhagic Fever, Turkey, 2022.

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Altay K., Elaldi N., Erol U., Koksal B., Sahin O. F., Pektas A. N., ...More

Emerging infectious diseases, vol.32, no.10, pp.1561-1570, 2026 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 32 Issue: 10
  • Publication Date: 2026
  • Doi Number: 10.3201/eid3210.251049
  • Journal Name: Emerging infectious diseases
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, Environment Index, MEDLINE, Public Affairs Index, Directory of Open Access Journals, Zoological Record, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
  • Page Numbers: pp.1561-1570
  • Open Archive Collection: AVESIS Open Access Collection
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

Anaplasma capra is a recently discovered bacterial tickborne

pathogen that was first identified in goats in 2012

and later in humans in China in 2015. We detected and

genetically characterized A. capra in adult patients with

suspected Crimean-Congo hemorrhagic fever (CCHF) in

Turkey during the 2022 outbreak. We screened all patients

for A. capra by using nested PCR targeting the

gltA and groEL genes. We confirmed CCHF by molecular

and serological tests. Of 263 patients, 6 (2.28%) were positive for A. capra. Sequence analysis revealed

84.16%–100% gltA gene similarity and 90.24%–100%

groEL gene similarity with GenBank entries. Phylogenetic

analysis confirmed all A. capra gene sequences

belonged to genotype 1. Our results demonstrate clinical

evidence of genotype 1 A. capra infection in humans.

Our findings highlight the need for clinicians to consider

A. capra in the differential diagnosis of CCHF-like symptoms,

especially in endemic areas.