Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft

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SARAÇ B., KORKMAZ Ö., ALTUN A., BAĞÇİVAN İ., GÖKSEL S., YILDIRIM Ş., ...Daha Fazla

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, cilt.21, sa.3, ss.342-345, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1093/icvts/ivv136
  • Dergi Adı: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.342-345
  • Anahtar Kelimeler: Moxonidine, Human radial artery, Relaxation, Coronary artery bypass graft, NITROGLYCERIN SOLUTION, PHENOXYBENZAMINE, PAPAVERINE, VASOSPASM, VERAPAMIL, SURGERY, SPASM
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms are a significant problem for a surgical team to overcome in the perioperative and postoperative period. In current surgical practice, the use of vasodilator agents perioperatively in the pending graft preparation is generally accepted and these may be implemented topically, endoluminally or both ways. Moxonidine is the latest second-generation, centrally acting antihypertensive agent, and the intention in this paper is to investigate its direct vasorelaxant effects and relaxation mechanisms on the human radial artery in vitro.