Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever

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Atıf İçin Kopyala

SANCAKDAR E., Guven A. S., UYSAL E. B., DEVECİ K., GÜLTÜRK E.

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.34, sa.8, 2015 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 34 Sayı: 8
• Basım Tarihi: 2015
• Doi Numarası: 10.1097/inf.0000000000000706
• Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection.