PREPARATION AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES CONTAINING INDENOPYRAZOLE DERIVATIVE COMPOUNDS

Doğan M., Gezegen H.

INTERNATIONAL GEVHER NESIBE HEALTH SCIENCES CONFERENCE-VII, Kayseri, Türkiye, 16 - 17 Nisan 2021, ss.233-234

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Kayseri
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.233-234
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In this study, it was aimed to prepare characterization studies such as preparing chitosan nanoparticles containing indenopyrazole derivatives, which were previously synthesized and characterized and bioactive potentials were determined, and measuring the encapsulation efficiency, particle size and zeta potential. Nanoparticles were prepared by ionic gelation method using chitosan and tripoly phosphate (TPP). The zeta potentials and particle sizes of the nanoparticles were measured in the Malvern Zeta Sizer. In order to calculate the encapsulation efficiency in nanoparticles, the absorbance of the indenopyrazole derivative samples at 278 nm wavelength was measured with a UV-visible spectrophotometer and spectral curve equations were formed. The zeta potential, size and encapsulation efficiency results of chitosan nanoparticles containing indenopyrazole derivatives are shown in Table 1. According to the results, the NP3 formulation containing the HZ4 coded derivative showed the highest encapsulation efficiency.