KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients


BAĞCI B. , SARİ M. , KARADAYI K. , TURAN M. , ÖZDEMİR Ö., BAĞCI G.

CANCER BIOMARKERS, vol.17, no.2, pp.133-143, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3233/cbm-160624
  • Title of Journal : CANCER BIOMARKERS
  • Page Numbers: pp.133-143

Abstract

BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes cause colorectal cancer development. Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis.