Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever

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Kaya S., Elaldı N., Kubar A., Gürsoy N., Yılmaz M., Karakuş G., ...More

BMC INFECTIOUS DISEASES, vol.14, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2014
  • Doi Number: 10.1186/1471-2334-14-416
  • Journal Name: BMC INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: CCHF, CCHFV titer, Specific IgG, TNF-alpha, IL-6, IL-10, IFN-gamma, DIC, Mortality, NECROSIS-FACTOR-ALPHA, CCHF VIRUS, LOAD, PATHOGENESIS, PREDICTOR, INFECTION, CORRELATE, EFFICACY, PLASMA, LETHAL
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

Background: Although there have been a number of studies on the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) recently, knowledge on this topic is still insufficient. This study aims to reveal the kinetics of serum CCHF virus (CCHFV) titers, serum levels of anti-CCHFV immunoglobulin (Ig) G, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, and interferon (IFN)-gamma in CCHF patients.