Quinoline-fused both non-peripheral and peripheral Zn-II and Mg-II phthalocyanines: Anti-cholinesterase, anti-alpha-glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Yalazan H., TÜZÜN B., AKKAYA D., BARUT B., KANTEKİN H., YILDIRMIŞ S.

APPLIED ORGANOMETALLIC CHEMISTRY, cilt.36, sa.7, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/aoc.6696
  • Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Anahtar Kelimeler: anti-cholinesterase, anti-alpha-glucosidase, molecular docking, phthalocyanine, PLIP-, ACETYLCHOLINESTERASE, DERIVATIVES, INHIBITION, COMPLEXES, DIAGNOSIS, ZINC(II), BINDING, FUZZY
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Quinoline-fused Zn-II (ZnPcp/ZnPcnp) and Mg-II (MgPcp/MgPcnp) phthalocyanines with four 4-methylquinolin-2-ol (1) at non-peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti-cholinesterase, anti-alpha-glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non-peripheral Zn-II and Mg-II phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and alpha-glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.