Cytotoxicity evaluation of methacrylate- and silorane-based composite resins

Bektas O. O. , EREN D., Akin G. G. , Polat Z.

Cumhuriyet Dental Journal, vol.15, no.4, pp.327-334, 2012 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.7126/cdj.2012.1699
  • Journal Name: Cumhuriyet Dental Journal
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.327-334


Objectives: The objective of this study was to investigate and compare the cytotoxic effects of four composite resin materials with different content. Material and Methods: Two traditional methacrylate-based (Clearfil AP-X, RefleXions), as well as a selfadhering methacrylate-based (Vertise Flow) and a silorane-based (Filtek Silorane) composite resin were tested in the experiment. Ten cylindrical specimens were made of each material, using a mould (2mm. thick and 8 mm. in diameter). An agar diffusion method was employed, and cytotoxicity rankings were determined using lysis index scores. For statistical analysis, Kruskal-Wallis and Mann-Whitney U-tests were used. Results: Amongst the composite resins, the silorane-based composite was found to be less cytotoxic than the methacrylate-based composite resins, which all had the same cytotoxicity ranking. Conclusions: The silorane-based composite resin was considered more biocompatible than the methacrylatebased composite resins.