Alternate Method for the Synthesis of Six-Membered Carbocycles with Five Stereocenters: 1,2,3,4,6-Pentasubstituted-4-hydroxy-cyclohexanes


Gezegen H. , Ceylan M.

SYNTHETIC COMMUNICATIONS, vol.45, pp.2344-2349, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45
  • Publication Date: 2015
  • Doi Number: 10.1080/00397911.2015.1080845
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.2344-2349

Abstract

A series of novel 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes (3a-u) were synthesized from the reaction of aromatic ketones with aromatic aldehydes under mild reaction conditions in good yields. The stereochemistry of the synthesized compounds was established using 1D and 2D-NMR spectra.