Increased Retinal Vessel Tortuosity Associated With Crimean-Congo Hemorrhagic Fever in Children.

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Yalinbas D., Komurluoglu A., Bozali E.

The Pediatric infectious disease journal, vol.40, pp.880-884, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2021
  • Doi Number: 10.1097/inf.0000000000003187
  • Journal Name: The Pediatric infectious disease journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.880-884
  • Keywords: Crimean-Congo hemorrhagic fever, retinal vessel tortuosity, children, retinal venous dilatation, conjunctival hyperemia, OCULAR COMPLICATIONS, PEDIATRIC-PATIENTS, VEGF-A, VIRUS, PATHOGENESIS, OUTBREAK
  • Sivas Cumhuriyet University Affiliated: Yes



Background: To evaluate the ocular symptoms and findings of children diagnosed with Crimean-Congo hemorrhagic fever (CCHF).

Methods: In this prospective study, children diagnosed with CCHF who underwent a complete ophthalmologic examination during the hospitalization period were included.

Results: Twenty-four children with a mean age of 12.4 ± 3.6 years were included study. The most common ocular finding was conjunctival hyperemia and was observed in 50% of patients. Nine (37.4%) children had abnormalities in fundus examination. Two (8.3%) of them had dilated retinal veins, and 7 (29.1%) had tortuous retinal vessels. No significant difference was found between mild to moderate and severe disease groups in terms of ocular symptoms and ophthalmologic examination findings (P > 0.05, for all).

Conclusions: The increased retinal vessel tortuosity was detected as a fundus examination finding in children with CCHF. Both ophthalmologists and pediatricians should be aware of the various ocular manifestations of CCHF for rapid diagnosis and management.