A novel sonication assisted dispersive liquid-liquid microextraction method for methylparaben in cosmetic samples using deep eutectic solvent

Altunay A. O. , ELİK A.

SUSTAINABLE CHEMISTRY AND PHARMACY, vol.29, 2022 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29
  • Publication Date: 2022
  • Doi Number: 10.1016/j.scp.2022.100781
  • Keywords: Methylparaben, Chemometric optimization, Deep eutectic solvents, Cosmetic samples, Green extraction, EXTRACTION, CHROMATOGRAPHY, PRODUCTS, PARABENS, PHASE


A simple, green and sensitive analytical methodology for extraction and determination of methylparaben (MP) in cosmetic samples, based on deep eutectic solvent-based sonication assisted dispersive liquid-liquid microextraction (DES-SA-DLLME) combined with UV-Vis spectrophotometry was optimized by using a central composite design (CCD). Herein, we prepared and tested six DES (as extraction solvent) for the selective extraction of MP. A mixture of 525 mu L of DES-3 (consisting of a 1:2:3 M ratio mixture of proline, malic acid and water, respectively) and 390 mu L THF (aprotic solvent) was used for the DES-SA-DLLME process. Under optimum conditions based on the CCD, the calibration graph showed high level of coefficient determination (R2:0.9978) for the MP in the range of 15-650 mu g L-1. The limit of detection and enrichment factor were 4.5 mu g L-1 and 148, respectively. The application of the DES-SA-DLLME method was investigated for the extraction and quantification of MP in selected cosmetic samples in micrograms per liter and quantitative analytical data were obtained (RSDs <3.8%). This method provides quantitative recoveries, less extraction time, and uses green solvents for the determination of trace MP in complex matrices.