Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats


Gursoy S., ÖZDEMİR E., BAĞÇİVAN İ., ALTUN A., DURMUŞ N.

UPSALA JOURNAL OF MEDICAL SCIENCES, vol.116, no.4, pp.238-246, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3109/03009734.2011.597889
  • Journal Name: UPSALA JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.238-246
  • Keywords: Dexmedetomidine, guanfacine, morphine, alpha(2)-receptor agonist, tolerance, ADRENERGIC-OPIOID SYNERGY, CATECHOLAMINE CELL GROUP, KNOCK-OUT MICE, PHYSICAL-DEPENDENCE, NITRIC-OXIDE, ANTINOCICEPTIVE TOLERANCE, SPINAL ANALGESIA, MECHANISMS, RECEPTORS, SUBTYPE
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats.