Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Gursoy S., ÖZDEMİR E., BAĞÇİVAN İ., ALTUN A., DURMUŞ N.

UPSALA JOURNAL OF MEDICAL SCIENCES, cilt.116, sa.4, ss.238-246, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/03009734.2011.597889
  • Dergi Adı: UPSALA JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.238-246
  • Anahtar Kelimeler: Dexmedetomidine, guanfacine, morphine, alpha(2)-receptor agonist, tolerance, ADRENERGIC-OPIOID SYNERGY, CATECHOLAMINE CELL GROUP, KNOCK-OUT MICE, PHYSICAL-DEPENDENCE, NITRIC-OXIDE, ANTINOCICEPTIVE TOLERANCE, SPINAL ANALGESIA, MECHANISMS, RECEPTORS, SUBTYPE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats.