Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats


Gursoy S., ÖZDEMİR E. , BAĞÇİVAN İ. , ALTUN A. , DURMUŞ N.

UPSALA JOURNAL OF MEDICAL SCIENCES, vol.116, no.4, pp.238-246, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3109/03009734.2011.597889
  • Title of Journal : UPSALA JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.238-246

Abstract

Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats.