UPSALA JOURNAL OF MEDICAL SCIENCES, vol.116, no.4, pp.238-246, 2011 (SCI-Expanded)
Article / Article
UPSALA JOURNAL OF MEDICAL SCIENCES
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Dexmedetomidine, guanfacine, morphine, alpha(2)-receptor agonist, tolerance, ADRENERGIC-OPIOID SYNERGY, CATECHOLAMINE CELL GROUP, KNOCK-OUT MICE, PHYSICAL-DEPENDENCE, NITRIC-OXIDE, ANTINOCICEPTIVE TOLERANCE, SPINAL ANALGESIA, MECHANISMS, RECEPTORS, SUBTYPE
Sivas Cumhuriyet University Affiliated:
Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats.