Akademik Veri Yönetim Sistemi
29th International Rhinocamp Congress, Muğla, Türkiye, 22 - 25 Mayıs 2025, (Özet Bildiri)
ORAL PRESENTATION 5-3 Evaluation of the Role of Triglyceride-Glucose Index in Sudden Hearing Loss Ahmet AKSOY MD, Tuba DOĞAN KARATAŞ MD Department of Otolaryngology–Head and Neck Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. Aim: Sudden Sensorineural Hearing Loss (SSNHL) is an otological emergency that typically requires immediate intervention, and its aetiology remains idiopathic mainly. In recent years, growing evidence has indicated that metabolic syndrome, insulin resistance, and vascular dysfunction may contribute to the pathophysiology of SSNHL. The triglyceride-glucose (TyG) index has emerged as a simple, reliable, and cost-effective biochemical marker for assessing insulin resistance, with increasing reports of its association with various cardiovascular and neurological disorders in the literature. This study aims to evaluate TyG index levels in individuals diagnosed with SSNHL retrospectively and to investigate the potential utility of this index as a biomarker for early diagnosis or prevention of the disease. Material and Method: Following the required approval from the institutional ethics committee (2025-01/164), this retrospective study was comprised of patients aged 18 to 65 diagnosed with sudden sensorineural hearing loss (SSNHL) between 2017 and 2024. Patients with complete fasting triglyceride (TG), fasting plasma glucose (FPG), and audiometric data (baseline and 3-month pure tone averages) were included in the study. Individuals with a documented history of chronic otitis media, otosclerosis, Meniere’s disease, or previous ear surgery were excluded. The TyG index was calculated as follows: TyG = ln [TG (mg/dL) × FPG (mg/dL)/2]. Audiometric outcomes were assessed at 500, 1000, 2000, and 4000 Hz, and the TyG index was analyzed based on hearing thresholds and modified Siegel criteria. Statistical analysis was conducted using R (v4.4.1) and JASP (v0.19.0), with significance set at p<0.05. Results: A total of 319 patients participated in the study, with a control group comprising 62.1% of the SSNHL group. No statistically significant differences were found between the groups regarding age, sex, glucose, or triglyceride levels. However, the TyG index was significantly higher in the SSNHL group (p=0.027). According to the modified Siegel criteria, TyG index values were significantly correlated with the severity of hearing loss and the degree of recovery (p<0.001). Spearman correlation analysis revealed significant positive correlations between the TyG index and hearing thresholds at various frequencies. Logistic regression analysis identified the TyG index as an independent risk factor for SSNHL, irrespective of age and sex (OR=1.48; p=0.024). Nevertheless, the area under the curve (AUC) analysis indicated that the TyG index had limited discriminatory power in identifying SSNHL (AUC=0.574), suggesting it may not be sufficient as a standalone diagnostic marker. Conclusion: This study is among the first to analyze the relationship between SSHL and the TyG index. The TyG index was identified as an independent risk factor for SSNHL and may serve as a potential predictive biomarker, particularly within multivariate models. Keywords: Triglyceride-Glucose Index, Sudden Hearing Loss, Biomarker, Otological emergency References 1. 2. 3. 4. 5. 6. Hong S, Han K, Park CY. The insulin resistance by triglyceride glucose index and risk for dementia: population-based study. Alzheimers Res Ther. 2021;13(1):9. Kaneva AM, Yanov YK, Bojko SG, Kudryavykh OE, Potolitsyna NN, Bojko ER, et al. The atherogenic index (ATH index) as a potential predictive marker of idiopathic sudden sensorineural hearing loss: a case-control study. Lipids Health Dis. 2019;18:64. Kojima Y, Ito S, Furuya N. Hearing improvement after therapy for hyperlipidemia in patients with chronic-phase sudden deafness. Ann Otol Rhinol Laryngol. 2001;110:105–8. Lee JS, Kim DH, Lee HJ, Kim HJ, Koo JW, Choi HG, et al. Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss. PLoS One. 2015;10:e0122496. Liu L, Qin M, Ji J, Wang W. Correlation between hearing impairment and the triglyceride glucose index: based on a national cross-sectional study. Front Endocrinol. 2023;14:1216718. Zhang Q, Xiao S, Jiao X, Shen Y. The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: evidence from NHANES 2001–2018. Cardiovasc Diabetol. 2023;22(1):279