Potassium-Tertiary Butoxide-Assisted Addition of Thioglicolic Acid to Chalcone Derivatives Under Solvent-Free Conditions


Ceylan M., Gurdere M. B. , Gezegen H. , Budak Y.

SYNTHETIC COMMUNICATIONS, vol.40, pp.2598-2606, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2010
  • Doi Number: 10.1080/00397910903291129
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.2598-2606

Abstract

A series of chalcone derivatives containing thioglicolic acid (4a-j) was prepared by addition of thioglicolic acid to the chalcones (3a-j) in the presence of KOt-Bu under solvent-free conditions. The mechanistic pathway of the reaction can be explained by the Michael-type addition of thioglicolic acid to chalcone derivatives (3a-j).