Strong association between lung cancer and the AXIN2 polymorphism


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GÜNEŞ E. G. , PINARBAŞI E. , PINARBAŞI H. , SİLİĞ Y.

MOLECULAR MEDICINE REPORTS, vol.2, no.6, pp.1029-1035, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.3892/mmr_00000210
  • Title of Journal : MOLECULAR MEDICINE REPORTS
  • Page Numbers: pp.1029-1035
  • Keywords: AXIN2, polymorphism, lung cancer, cancer predisposition, Turkish population, BETA-CATENIN, COLORECTAL-CANCER, GENETIC-POLYMORPHISM, SOMATIC MUTATIONS, BREAST-CANCER, RISK, POPULATION, CARCINOGENESIS, ADENOCARCINOMA, AMPLIFICATION

Abstract

Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 exon 1 148 C -> T polymorphism was recently investigated in a Japanese population, but has not been investigated in other populations. Additionally, other common polymorphisms of this gene have not been studied. In the present study, 8 polymorphisms of the AXIN2 gene, including exon 1 148 C -> T, were investigated in a Turkish population of 100 lung cancer patients using PCR-RFLP methods. For the exon 1 432 C -> T, exon 5 1365 G -> A, exon 5 1386 C -> T, intron 5 1712+19 G -> T, exon 7 2062 C -> T and intron 7 2141+73 G -> A single nucleotide polymorphisms of AXIN2, no significant association was found between the controls and the lung cancer patients. For exon 1 148 C -> T, a statistically significant association between the controls and lung cancer patients was found. For this region, lung cancer patients with the TT genotype showed a decreased risk [odds ratio (ORTT) 0.33, 95% confidence interval (CI) 0.12-0.89; p=0.032 (adjusted for, gender and smoking status)] as compared with the controls age. with the CC genotype. Concerning histological tumor type, it has been found that exon 1 148 C -> T SNP is associated with a significant decreased risk in squamous cell carcinoma patients (ORTT 0.16; 95% CI 0.03-0.79; p=0.014). Male (ORTT 0.19; 95% CI 0.4-0.77; p=0.015) and smoker (ORTT 0.11; 95% CI 0.01-0.71; p=0.019) lung cancer patients with the TT genotype showed a decreased risk for the same region. Our results suggest that the risk of lung cancer in a Turkish population is related to poly morph isms of the AXIN2 gene.