ANTI-INFLAMMATORY ACTIVITY OF TURKEY SOURCE PUMPKIN SEED OIL IN RAT EDEMA MODEL

ARSLANBAŞ E., KARA H., KARAYİĞİT M. Ö., DOĞAN H. O., Yildiz S. N.

ACTA POLONIAE PHARMACEUTICA, vol.77, no.2, pp.305-312, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.32383/appdr/118962
  • Journal Name: ACTA POLONIAE PHARMACEUTICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chimica, EMBASE, International Pharmaceutical Abstracts
  • Page Numbers: pp.305-312
  • Keywords: pumpkin seed oil, carrageenan, anti-inflammatory, edema model, indomethacin, rat
  • Sivas Cumhuriyet University Affiliated: Yes

Abstract

This study aimed to determine the effects of Turkey-sourced pumpkin seed oil (PSO), administered orally to rats in different dosages, to research its anti-inflammatory effect in rat edema model, induced by carrageenan, based on different dosages, and to evaluate its effects comparatively with indomethacin. The study was conducted on 42 rats in total, divided into 7 groups (control, carr, PSO40, PSO100, PSO40+carr,PSO100+carr and indo+carr). In the study, doses of 40 and 100 mg/kg of PSO were found to significantly sup-press rat paw edema in time, and it was observed that this effect was more pronounced in the fourth hour. It was found that MDA and cytokine (TNF-alpha, IL-6, IL-1 beta) levels were inhibited, and GPX and SOD activities were enhanced in groups that received PSO and indo+carr groups. Histopathological examinations also support these findings. As a result of the study, the significant anti-inflammatory effect of Turkey-sourced PSO was attributed to the existence of unsaturated fatty acids and enriched phytochemical compounds.