Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter


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KOYUNCU A. , BAĞÇİVAN İ. , SARAÇ B. , Aydin C., YILDIRIM Ş. , SARIOĞLU Y.

WORLD JOURNAL OF GASTROENTEROLOGY, vol.14, no.29, pp.4667-4671, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 29
  • Publication Date: 2008
  • Doi Number: 10.3748/wjg.14.4667
  • Title of Journal : WORLD JOURNAL OF GASTROENTEROLOGY
  • Page Numbers: pp.4667-4671

Abstract

AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle.