The effect of taxifolin on oxidative ovarian damage and reproductive dysfunctions induced by antipsychotic drugs in female rats.

Ince S., Ozer M., Kadioglu B. G., Kuzucu M., Ozkaraca M., Gezer A., ...Daha Fazla

The journal of obstetrics and gynaecology research, cilt.47, ss.2140-2148, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/jog.14769
  • Dergi Adı: The journal of obstetrics and gynaecology research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.2140-2148
  • Anahtar Kelimeler: antioxidant activity, clozapine, haloperidol, pregnancy, taxifolin
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Aim Typical antipsychotics (TAPs) are commonly used to treat schizophrenia and bipolar disorder. However, extrapyramidal disorders, hyperprolactinemia, and reproductive dysfunctions have been observed in women during the use of TAPs. For this reason, less toxic and prolactin-sparing atypical antipsychotic (AAP) drugs such as clozapine (CLN) have been developed. The aim of this study is to investigate the effect of taxifolin on possible ovarian and reproductive toxicity associated with CLN and haloperidol (HPL) in female Wistar albino rats.