Free vitamin D and vitamin D binding protein in multiple sclerosis patients

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Donmez R., Yildiz O. K., Gorgulu U.

Neurology Asia, cilt.28, sa.3, ss.683-686, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.54029/2023hhe
  • Dergi Adı: Neurology Asia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.683-686
  • Anahtar Kelimeler: free vitamin D, Multiple sclerosis, vitamin D, vitamin D binding protein
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: In multiple sclerosis (MS), where low vitamin D level is a risk factor, there is no previous study evaluating the level of free vitamin D by direct measurement, and there is little information about vitamin D binding protein (DBP). This study assessed free vitamin D and DBP in patients with MS. Methods: The study subjects consisted of 43 MS patients and 25 controls. Free vitamin D and DBP levels were measured through an enzyme-linked immunosorbent (ELISA) kit. Results: The patient group had a mean age of 36.58 ± 9.4 (19-60) and the control group had a mean age of 33.56 ± 9.65 (24-52) years (p=0.210). The patient had free vitamin D level of 21.51 ±9.72 pg/ml and the free vitamin D level of the control group was 26.02 ±9.29 pg/ml. Free vitamin D levels did not significantly differ across the groups (p=0.065). The patient group (34.78 ±18.24 ng/ml) had a significantly higher DBP level than the control group (15.36 ±10.64 ng/ml) (p<0.001). Conclusion: MS patients have higher DBP than healthy control, while the free vitamin D levels of the patients tend to be lower.