PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Clyman R. I. , Liebowitz M., Kaempf J., Erdeve O., Bulbul A., Hakansson S., ...More

JOURNAL OF PEDIATRICS, vol.205, pp.41-54, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 205
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jpeds.2018.09.012
  • Title of Journal : JOURNAL OF PEDIATRICS
  • Page Numbers: pp.41-54


Objective To compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given.