Angiotensin receptor-neprilysin inhibition by sacubitril/valsartan attenuates doxorubicin-induced cardiotoxicity in a pretreatment mice model by interfering with oxidative stress, inflammation, and Caspase 3 apoptotic pathway

Dindaş F., Güngör H., Ekici M., Akokay P., Erhan F., Doğduş M., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.25, sa.11, ss.821-828, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5152/anatoljcardiol.2021.356
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.821-828
  • Anahtar Kelimeler: sacubitril, valsartan, doxorubicin, cardiotoxicity, heart failure, INDUCED CARDIOMYOPATHY, CANCER-THERAPY, TNF-ALPHA, ADRIAMYCIN, DYSFUNCTION, ARRHYTHMIAS, MECHANISMS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Doxorubicin (DOX) is a well-known cardiotoxic agent, whereas sacubitril/valsartan (Sac/Val) is an effective treatment option in heart failure. In this study, we aimed to evaluate the effect of Sac/Val on DOX-induced cardiotoxicity in pretreatment mice model.