Mobbing is the leading problem of organizations in developed countries and it has also become an important issue in Turkey. Especially, mobbing is very common problem in higher education. The main aim of the study is to examine the mediating roles of social safeness and pleasure in the relationship between the meaning of the work and mobbing. The study group was selected by using a convenience sampling (ease of access) and totally 486 university lecturers and faculty members from 58 various universities of Turkey were included in the study. Participants filled in Mobbing Scale, Social Safeness and Pleasure Scale, Work and Meaning Inventory. Pearson product moment correlation analysis and stepwise linear regression analysis techniques were used in order to detect the direction and level of the relationships between parameters since data were normally distributed and Kolmogorov-Smirnov scores of data were insignificant. According to the mediating analysis findings, social safeness and pleasure are the partial reason for the relationship between mobbing and meaning of the work. As the mobbing level increases, the social safeness and pleasure decrease and this decrease also lower the academicians' meaning of work.