Determination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentation


Kucukoflaz M., SARAÇOĞLU KAYA B. , ÇAĞLAYAN M. O.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS, vol.58, no.7, pp.765-775, 2019 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 7
  • Publication Date: 2019
  • Doi Number: 10.1080/03602559.2018.1520252
  • Title of Journal : POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
  • Page Numbers: pp.765-775

Abstract

In this study, we synthesized poly (vinyl acetate-co-divinyl benzene) microspheres with various monomer/cross-linker contents for oral/topical sustained drug release applications and determined the micromechanical properties by nanoindentation. Compression elastic moduli of materials were calculated by using the limited depth of indentation according to Hertz elastic deformation model and presented as the histogram of multiple data. In terms of drug release practices, poly (VAc-co-DVB) microspheres with a high DVB content, especially in topical applications, are expected to carry drugs under mechanical stresses of less than 1.0 GPa.