Determination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentation

Kucukoflaz M., SARAÇOĞLU KAYA B., ÇAĞLAYAN M. O.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS, cilt.58, sa.7, ss.765-775, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/03602559.2018.1520252
  • Dergi Adı: POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.765-775
  • Anahtar Kelimeler: Controlled drug release, drug delivery systems, polymeric microsphere, nanoindentation, nanomechanical properties, CONTROLLED-RELEASE, BEADS, PARTICLES, HYDROGEL, ALGINATE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In this study, we synthesized poly (vinyl acetate-co-divinyl benzene) microspheres with various monomer/cross-linker contents for oral/topical sustained drug release applications and determined the micromechanical properties by nanoindentation. Compression elastic moduli of materials were calculated by using the limited depth of indentation according to Hertz elastic deformation model and presented as the histogram of multiple data. In terms of drug release practices, poly (VAc-co-DVB) microspheres with a high DVB content, especially in topical applications, are expected to carry drugs under mechanical stresses of less than 1.0 GPa.