Silver nanoparticle/capecitabine for breast cancer cell treatment


HEPOKUR C. , KARİPER İ. A. , MISIR S. , Ay E., Tunoglu S., Ersez M. S. , ...More

TOXICOLOGY IN VITRO, vol.61, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2019
  • Doi Number: 10.1016/j.tiv.2019.104600
  • Title of Journal : TOXICOLOGY IN VITRO

Abstract

This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.