Silver nanoparticle/capecitabine for breast cancer cell treatment


HEPOKUR C. , KARİPER İ. A. , MISIR S. , Ay E., Tunoglu S., Ersez M. S. , ...Daha Fazla

TOXICOLOGY IN VITRO, cilt.61, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.