Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis


GÜMÜŞ M., Ozgur A., Tutar L., DİŞLİ A., KOCA İ., TUTAR Y.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, cilt.17, ss.1231-1245, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 14
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2174/1389201017666161031105815
  • Dergi Adı: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Sayfa Sayıları: ss.1231-1245

Özet

Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target for drug design. For this purpose, a series of benzodiazepine derivatives were designed and synthesized as novel Hsp90 inhibitor.