ANALYSIS OF IL-6, IL-10 AND NF-kappa B GENE POLYMORPHISMS IN AGGRESSIVE AND CHRONIC PERIODONTITIS


Creative Commons License

TOKER H. , Gorgun E. P. , KORKMAZ E. M.

CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH, vol.25, no.2, pp.157-162, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.21101/cejph.a4656
  • Title of Journal : CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
  • Page Numbers: pp.157-162
  • Keywords: periodontitis, polymorphism, NF-kappa B, IL-6, IL-10, INTERLEUKIN-10 GENE, PROMOTER POLYMORPHISMS, INFLAMMATORY DISEASES, NFKB1 PROMOTER, ASSOCIATION, SUSCEPTIBILITY, METAANALYSIS, POPULATION, EXPRESSION, HAPLOTYPE

Abstract

Objective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-kappa B(NF-kappa B). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-kappa B1-94ins/del)) and chronic/aggressive periodontitis.