Increased Levels of VEGF-A and HIF-1 alpha in Turkish Children with Crimean-Congo Hemorrhagic Fever

Sefikogullari M., Kaya A. , Aydın H. , Sancakdar E. , Çelik V. K. , Bağcı G.

JOURNAL OF ARTHROPOD-BORNE DISEASES, cilt.11, ss.19-26, 2017 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2017
  • Sayfa Sayıları: ss.19-26


Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1 alpha (HIF-1 alpha) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1 alpha and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease.