The role of immature granulocytes as a novel biomarker in migraine: a prospective tertiary-care study Az éretlen granulocyták szerepe új biomarkerként migrénben: prospektív, harmadlagos ellátási szintű tanulmány
Ideggyogyaszati Szemle, cilt.79, sa.9-10, ss.329-339, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 79 Sayı: 9-10
- Basım Tarihi: 2026
- Doi Numarası: 10.18071/isz.79.0329
- Dergi Adı: Ideggyogyaszati Szemle
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.329-339
- Anahtar Kelimeler: complete blood count, immature granulocyte, inflammatory indices, migraine, systemic inflammation, systemic inflammation response index
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Background and purpose – Migraine has been associated with systemic inflammatory alterations in a limited number of studies, although the evidence remains inconsistent. In this context, immature granulocytes (IGs), early indicators of bone marrow activation, have been proposed as potential biomarkers in migraine research. The aim of this study was to evaluate IG levels in patients with episodic migraine during attack and interictal periods and to investigate their relationship with hematological inflammatory markers and clinical features. Methods – This prospective case-control study enrolled 53 patients with episodic migraine and 53 healthy controls matched for age and sex. Blood samples were collected during acute migraine attacks and interictal periods. Inflammatory parameters, including IG, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-tomonocyte ratio (LMR), systemic inflammation response index (SIRI), and platelet indices were analyzed. Correlations with clinical characteristics such as headache frequency, aura, white matter lesions, and migraine disability assessment scale (MIDAS) scores were assessed. Results – IG levels did not differ significantly between migraineurs and controls. However, lower IG levels were associated with higher headache frequency (ρ =-0.453, p = 0.001) and MIDAS scores (ρ =-0.291, p = 0.037). LMR was significantly lower and SIRI higher in the attack-period patients versus con trols (p = 0.028 and p = 0.023, respectively). Platelet indices such as MPV, PDW, and P-LCR elevated during attacks, while platelet counts increased during interictal periods. ROC analyses showed limited discriminative power of platelet indices (AUC < 0.61). Conclusion – These findings suggest that IG levels and inflammatory indices such as LMR and SIRI may reflect migraine-related immune activity and disease burden during the migraine attack phase, though their clinical utility requires further validation.