Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever

ENGİN A., ARSLAN S., Kizildag S., Ozturk H., ELALDI N., DÖKMETAŞ İ., ...Daha Fazla

MICROBES AND INFECTION, cilt.12, ss.1071-1078, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.micinf.2010.07.012
  • Dergi Adı: MICROBES AND INFECTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1071-1078
  • Anahtar Kelimeler: Crimean, Congo hemorrhagic fever, Toll like receptor 8, Toll like receptor 9, Polymorphism, NECROSIS-FACTOR-ALPHA, HUMAN PLATELETS, INFECTION, RECOGNITION, INNATE, TOLL-LIKE-RECEPTOR-9, POPULATION, EXPRESSION, INFLUENZA, IMMUNITY
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever The clinical course and outcome of the CCHF infection are different in humans Toll like receptors (TLRs) are a family of pathogen recognition receptors TLR8 and TLR9 contribute to the recognition of viruses We investigated frequency of TLR8 Met1 Val TLR8 -129C/G TLR9 -1486T/C and TLR9 2458G/A polymorphisms in CCHF patients and healthy controls Our study was conducted between June 1 and August 31 2007 in Cumhuriyet University Hospital, Turkey TLR genotypes were detected using the PCR-RFLP assay in 85 CCHF patients and 171 healthy controls We found that heterozygous plus homozygous mutant genotypes frequency for TLR8 Met1 Val and for TLR9 -1486T/C were significantly higher in CCHF patients than controls (p = 0 038 and p = 0 009, respectively) The frequency of TLR8 -129G/G genotype in the fatal CCHF patients was significantly higher than that of the non-fatal patients (p = 0 026) The frequency of TLR9 -1486C/C genotype was significantly higher in fatal CCHF patients than in healthy controls (p = 0 009) and in patients with severe disease compared to non severe disease (p = 0 044) Our findings suggest that TLR8 Met1 Val TLR8 -129C/G and TLR9 -1486T/C polymorphisms are important on clinical course of CCHF disease (C) 2010 Institut Pasteur Published by Elsevier Masson SAS All rights reserved