The role of SCUBE1 in the development of late stent thrombosis presenting with ST-elevation myocardial infarction

Bolayir H. A. , Kivrak T., Gunes H., Akaslan D., Sahin O., BOLAYIR A.

REVISTA PORTUGUESA DE CARDIOLOGIA, cilt.37, ss.375-381, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 37 Konu: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.repc.2017.07.015
  • Sayfa Sayıları: ss.375-381


Introduction and Aim: There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death. High platelet reactivity is a risk factor for thrombotic events, including late ST. For this reason, in the current study, we researched the rote of SCUBE1 in the development of late coronary ST.