Chemical Synthesis and Characterization of Lanthanum(III) 2-Hydroxybenzoate and Its Antibacterial Potential: In Vitro and In Silico Approaches
ACS Omega, cilt.11, sa.24, ss.35762-35775, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 24
- Basım Tarihi: 2026
- Doi Numarası: 10.1021/acsomega.6c02200
- Dergi Adı: ACS Omega
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Directory of Open Access Journals
- Sayfa Sayıları: ss.35762-35775
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
A novel lanthanum(III) salicylate complex (La(Sa)3) with potential biomedical applications was chemically synthesized via the reaction of salicylic acid (SA) with lanthanum oxide nanoparticles (La2O3NPs). This two-step synthesis approach involved the initial preparation of La2O3NPs followed by their coordination with mixed SA ligands, after which the resulting complex and its precursors were comprehensively characterized. The structure of the La(Sa)3 complex was investigated using nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), and transmission electron microscopy (TEM). Molecular docking studies of the newly synthesized complex were conducted to elucidate the interactions between La(Sa)3 and the target microbial protein at the molecular level. Comparative evaluations of the bacteriostatic and bactericidal activities of the La(Sa)3 complex, its ligand (SA), and La2O3NPs were performed against Gram-positive and Gram-negative bacteria. These studies demonstrated that the La(Sa)3 complex exhibited significant antibacterial activity against the selected bacterial strains. The results further indicated that La(Sa)3 showed enhanced antibacterial properties due to a synergistic effect with La2O3NPs. The morphology of the La(Sa)3 complex revealed that the chemical synthesis of the La(Sa)3 complex in the presence of La2O3NPs resulted in notable differences in powder and particle morphology. Spectral analyses confirmed that the synthesized La2O3NPs successfully reacted with SA to form La(Sa)3 complex molecules. The data obtained from the in silico studies were consistent with the results of the experimentally conducted antibacterial assays. The experimental study results suggest that the La(Sa)3 complex may be developed as a promising antibacterial drug candidate.