Pentraxin-2 is Associated with Renal Fibrosis in Patients Undergoing Renal Biopsy

Basturk T., Ojalvo D., Mazi E. E., Hasbal N. B., Ozagari A. A., Ahbap E., ...Daha Fazla

CLINICS, cilt.75, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75
  • Basım Tarihi: 2020
  • Doi Numarası: 10.6061/clinics/2020/e1809
  • Dergi Adı: CLINICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

OBJECTIVES: Progressive renal disease is characterized by histological changes in the kidney and fibrosis is a common outcome. Renal biopsy is the only diagnostic tool to evaluate these histopathological changes. Pentraxin-2 (PTX-2) is an anti-inflammatory constitutive plasma protein associated with the innate immune system. Recently, as a biomarker, the circulating level of PTX-2 is shown to be decreased in chronic fibrotic diseases. In this study, we aimed to investigate the relationship between renal fibrosis severity and serum PTX-2 levels in patients undergoing renal biopsy.