ARYLATION OF ANILINE AND AMINES BY Pd-(N-HETEROCYCLIC CARBENE) COMPLEXES


ŞAHİN N. , DEMİR DÜŞÜNCELİ S., ÖZDEMİR İ.

HETEROCYCLES, cilt.94, ss.1506-1517, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 94 Konu: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3987/com-17-13737
  • Dergi Adı: HETEROCYCLES
  • Sayfa Sayıları: ss.1506-1517

Özet

Aminoarenes constitute valuable building blocks in organic synthesis and an essential skeleton ubiquitously found in ligands, agrochemicals, and pharmaceuticals. This synopsis presents recent amination methods using nitrogen-heteroatom bonds as a powerful and versatile platform to rapidly synthesize diverse aminoarenes, with transition-metal catalyzed arene C-H amination. The Buchwald-Hartwig amination has been investigated theoretically and experimentally to examine the scope of possible bases under different reaction conditions. We report examples of the palladium NHC (N-heterocyclic carbene) catalyzed amination of aryl halides with anilines and amines in the presence of dimethoxyethane solvent and potassium tertiary-butoxide as a base.