SELECTIVE-INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION BY SYMPATHECTOMY IN RABBIT CAROTID-ARTERY RINGS INVITRO

KARS H., UTKAN T., SARIOGLU Y., YARADANAKUL V.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, cilt.15, sa.1, ss.35-40, 1993 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 1993
  • Dergi Adı: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.35-40
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

The influence of cervical and periarterial sympathectomy on endothelium-dependent relaxation of the rabbit common carotid artery was studied in vitro. Noradrenaline, serotonin, acetylcholine and papaverine concentration-response curves of sympathectomized and control rabbit common carotid artery rings were recorded and analyzed and effects of endothelium removal were investigated. Endothelium-dependent relaxation was selectively and significantly inhibited in 3 weeks postsympathectomy arterial preparations. Alterations in acetylcholine receptors of endothelial cells, decrease in endothelium-derived relaxing factor synthesis, or desensitization of medial muscular cells to endothelium-derived relaxing factor are hypothetical causes of this phenomenon.