In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels


Karadag E., Saraydin D. , Cetinkaya S., Guven O.

BIOMATERIALS, cilt.17, ss.67-70, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/0142-9612(96)80757-5
  • Dergi Adı: BIOMATERIALS
  • Sayfa Sayıları: ss.67-70

Özet

In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution-and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are incubated in 10 different human sera for 24 h and their biocompatibilities with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide/crotonic and acrylamide/itaconic acid hydrogels are biocompatible.