The Doppler signal of mitral valve is a biomedical signals and it is acquired by Doppler ultrasound device from mitral valve of hearth. It contains useful information about mitral valve and it can be used to diagnose mitral valve diseases by doctors. However, biomedical signal might be contaminated with noise or disruptive interference. In literature, different approaches have been introduced to remove the noise or interference from biomedical signal, but adaptive filtering is most popular technique for noise filtering. Therefore, a novel adaptive noise cancellation techniques based FIR digital filter was proposed using artificial bee colony algorithm (ABC) and it is employed for the noise reduction on noisy mitral valve Doppler signal. So, the meaningful data about mitral valve was saved to diagnose mitral valve diseases using denoising approach. Then, this novel approach was compared with the other methods suggested in literature such as recursive least square (RLS) algorithm or discrete wavelet transform (DWT). Also, to demonstrate the efficiency, different digital filter order and noise cases were used suggested in literature.