Development and validation an HPLC-UV method for determination of esomeprazole and pirfenidone simultaneously in rat plasma: application to a drug monitoring study


DURAL E. , Koz S. T. , KÖZ S.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.1, pp.16-25, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2020.0091
  • Title of Journal : ISTANBUL JOURNAL OF PHARMACY
  • Page Numbers: pp.16-25

Abstract

Background and Aims: It has been observed that the combined treatment of esomeprazole and pirfenidone provides increased efficacy in the treatment of pulmonary fibrosis disease, recently. The aim of this study is to develop a simple, sensitive, and reliable high-performance liquid chromatography method to be used in drug monitoring to increase the effectiveness of esomeprazole and pirfenidone in treatment and to reduce their adverse effects.