Development and validation an HPLC-UV method for determination of esomeprazole and pirfenidone simultaneously in rat plasma: application to a drug monitoring study
ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.1, ss.16-25, 2021 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.26650/istanbuljpharm.2020.0091
- Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.16-25
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Background and Aims: It has been observed that the combined treatment of esomeprazole and pirfenidone provides increased efficacy in the treatment of pulmonary fibrosis disease, recently. The aim of this study is to develop a simple, sensitive, and reliable high-performance liquid chromatography method to be used in drug monitoring to increase the effectiveness of esomeprazole and pirfenidone in treatment and to reduce their adverse effects.