The Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension

YILDIRIM M. E., BERK S., KÜÇÜK KURTULGAN H., TEKİN G., TEKİN Y. K., BAŞER B., ...Daha Fazla

GAZI MEDICAL JOURNAL, cilt.32, sa.1, ss.28-32, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.12996/gmj.2021.06
  • Dergi Adı: GAZI MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.28-32
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by obstructed airflow in the lungs. Pulmonary hypertension (PH) is a common complication of COPD and it is associated with pulmonary vascular remodelling. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines associated with migration of monocytes and macrophages. Both MCP-1 and its receptor CCR2 have been declared to be involved in various diseases. We aimed to research a possible association of MCP-1 level, MCP-1-2518 A/G and CCR2 190 A/G polymorphisms with COPD and pulmonary hypertension in this study.