Akademik Veri Yönetim Sistemi
Journal of Molecular Structure, cilt.1355, 2026 (SCI-Expanded, Scopus)
The present study explores the synthesis, characterization, α-glucosidase and aldose reductase inhibitory activities of some novel benzothiazole-thiadiazole hybride compounds. All compounds exhibited a higher potential of aldose reductase (AR) inhibition (KI: 4.816 ± 0.342–19.47 ± 1.726 nM and IC50: 5.698–12.560 nM) compared to the reference inhibitor epalrestat (KI: 756.342 ± 52.874 nM, IC50: 787.142 nM), along with higher α-glucosidase (α-GLY) inhibitory activity (KI: 0.413 ± 0.032–20.971 ± 2.035 µM and IC50: 0.616–31.247 µM) relative to acarbose (KI: 119.43 ± 10.65 µM and IC50: 136.28 µM). Among the tested compounds, especially compounds 4a (KI: 4.816 ± 0.342 nM), 4b (KI: 6.244 ± 0.456 nM), and 4i (KI: 5.260 ± 0.386 nM) stand out as the most potent AR inhibitors while compounds 4b (KI: 1.166 ± 0.097 µM) and 4c (KI: 0.413 ± 0.032 µM) come forward as the strongest candidates for α-GLY inhibition. Also, in silico molecular docking studies of the most potent compounds 4a, 4b, 4c and 4i are performed to evaluate interactions between the active compound and binding site of the tested enzymes. Furthermore, the predicted ADMET characteristics of these compounds was calculated using QikProp to gain insights into their drug-like properties. Cytotoxicity study was performed with the L929 fibroblast cell line in vitro revealed that all the synthesized compounds were non-cytotoxic.