Akademik Veri Yönetim Sistemi
HUMAN AUTOIMMUNITY AND ASOCIATED DİSEASES, DEMİR KENAN,GÖRGÜN SELİM, Editör, Cambridge University Press, Cambridge (MA), USA , Cambridge, ss.132-148, 2021
Many mechanisms, molecular and cellular events, and responses are
interferenced under autoimmunity. The dynamic biological system formed
by the realization of the laws of the sciences of chemistry and physics is
constantly in motion in maintaining metabolic activities in the body, in the
fight against foreign molecules, in the formation of the immune response,
and in the realization of autoimmune reactions. The formation of the
immune response in living systems, the synthesis and interactions of
molecules that occur during the immune response, and even the molecules
that cause the immune response are all regulated with biological reactions
maintained by chemical mechanisms. There is a constant chemical activity
in the form of molecule synthesis, and the defense and destruction of foreign
molecules for the continuity of life in the organism. Some immune
responses emerge immediately after encountering a foreign molecule or
molecules. Polypeptides for which the immune system is normally selftolerant can create autoimmune responses, if changed. Self-peptides can be
changed with genetic and epigenetic mechanisms. An autoimmune reply
can also result from native antibodies, changed peptides and self-antigens.
Native autoantibodies can function as template molecules for the obtaining
of pathogenic autoantibodies (Atassi and Casali 2008). Clinicians follow the
increasing gamma globulin, the deposition of denatured gamma globulin,
and the accumulation of lymphocytes and plasma cells to diagnose an
autoimmune state (Lester and King 1963).