Akademik Veri Yönetim Sistemi
1st INTERNATIONAL HEALTH SCIENCE AND LIFE CONGRESS, Burdur, Türkiye, 2 - 05 Mayıs 2018, ss.563
Gut microbiota is accepted as an '' organ '' activity due to its important role on the metabolic homeostasis and the formation of an immune response in the body. It has also been reported that gut microbiota has some beneficial effects on human health, as well as in the case of adverse conditions such as a dysbiyosis, it paves the way for the formation of certain diseases. Nutritional habits are important factors in the change of gut microbiota composition. De Filippo et al., compared Italian and African children with two different types of diet patterns and found different Firmicutes and Bacteriodetes ratios between the two groups. This difference has been shown to affect energy homeostasis through bacterial metabolites. In some studies in mice and humans, it has been reported that the ratio of Firmicutes and Bacteriodetes species has changed and is closely linked to obesity.In a study conducted by Tremoli et al., obesity-related metabolic complications and increased adipose tissue masses were observed in fecal microbiota samples taken from obese women as a result of microbiota-sterilized transfer to mice. However, in a universal meta-analysis study, it was noted that Bacteriodetes rates and weight or body mass indexes (BMI) were not associated with obese subjects. The relationship between obesity and gut microbiota is explained by various mechanisms. The first of these, short chain fatty acids (SCFA), increases triglycerides accumulation and lipogenesis. The second mechanism is that the changing intestinal microbial pattern suppresses AMPK activity. As a consequence, fat oxidation is reduced and fat texture is increased. Third, increased levels of lipopolysaccharides (LPS) derived from the metabolism of intestinal microbiota trigger systemic inflammation and interfere with obesity. As a result, the relationship between obesity and gut microbiota has not been fully elucidated and more research is needed in this regard.