In vivo and in vitro evidence for pleiotropic effects of levosimendan in the intensive care setting

YILMAZ M. B. , Mebazaa A.

CRITICAL CARE, vol.15, no.4, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 15 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1186/cc10308
  • Title of Journal : CRITICAL CARE


Levosimendan, in addition to its inotropic properties, could have anti-inflammatory and anti-oxidative properties, and can potentially decrease the deleterious effects of reactive oxygen species on the tissues. In their study, Hasslacher and colleagues provided not only in vitro but also in vivo evidence that levosimendan could preserve organ function in acute heart failure and septic-shock-induced myocardial depression via cooling down the oxidative burst of circulating cells.